GS-441524 is an antiviral drug that has gained attention for its effectiveness in treating feline infectious peritonitis (FIP), a fatal viral disease in cats caused by a mutation of the feline coronavirus (FCoV). FIP is typically hard to treat and was previously considered almost always fatal, especially in its wet and dry forms. GS-441524 has shown promising results in saving cats diagnosed with FIP.
GS-441524 is a nucleoside analog, meaning it mimics the building blocks of viral RNA. It works by inhibiting the replication of the feline coronavirus, thereby preventing the virus from multiplying and spreading within the cat’s body.
GS-441524 has been used to treat both wet (effusive) and dry (non-effusive) forms of FIP. Cats treated with GS-441524 have shown remarkable improvement, with many experiencing remission of symptoms such as fever, lethargy, weight loss, fluid accumulation, and neurological issues.
| Product Name | GS-441524 |
|---|---|
| CAS | 1191237-69-0 |
| Storage Condition | Room Temperature |
| Expiry Date | 1 Years From The Date Of Manufacture |
| Country of Manufacture | China |
| Packaging | 10 tablets/bag |
| Dosage Form | Oral |
| Function | Treatment For Cat FIP |
| Strength | 20mg, 40mg, 50mg and 60mg |
| Key Words | GS441524, GS441, Remdesivir intermediate |
"FIP" refers to Feline Infectious Peritonitis (FIP), which is a viral disease caused by certain strains of feline coronavirus (FCoV).
Cause: FIP is caused by a mutation of the feline coronavirus (FCoV). Most cats with FCoV do not develop FIP, but in some cases, the virus mutates into a form that causes FIP.
Transmission: FCoV is commonly spread through feces and oral-fecal transmission, often in multi-cat environments such as shelters or catteries. Once a cat is infected with FCoV, it may develop either a mild, self-limiting form of the disease or progress to FIP.
Forms of FIP: FIP presents in two main forms: effusive (wet) and non-effusive (dry). Effusive FIP involves the accumulation of fluid in body cavities, such as the abdomen or chest. Non-effusive FIP is characterized by granulomatous lesions in various organs.
Symptoms: Symptoms of FIP can vary widely and may include fever, weight loss, lethargy, jaundice, difficulty breathing, and fluid accumulation in the abdomen or chest in the case of effusive FIP. Neurological symptoms can also occur in some cases.
Diagnosis: FIP can be challenging to diagnose definitively, as clinical signs and laboratory tests are often non-specific. Diagnosis may involve a combination of clinical evaluation, laboratory tests (such as bloodwork, imaging, and fluid analysis), and sometimes histopathology.
Treatment: Unfortunately, there is no cure for FIP, and treatment options are limited. Supportive care to manage symptoms and improve quality of life is the main approach. Some medications may be used to alleviate inflammation or suppress the immune response, but they are not curative.
Prevention: Prevention of FIP focuses on reducing exposure to FCoV. This includes minimizing stress, maintaining good hygiene and sanitation practices, and reducing overcrowding in multi-cat environments. Vaccines for FIP are available, but their efficacy remains controversial.
Recommended dosage: 10mg/KG * body weight kg
Taking time: Both taken before and after meals is ok. It is recommended to take it at a fixed time every day.
Taking method: Take it directly. If the cat does not eat it, it can also be mixed in the feed.
Storage: Store at room temperature or Store at 2~4 ° C. Avoid light. Shelf life is one year.
Recommended treatment for 12 weeks.
