CAS 1191237-69-0 GS-441524 The Key Intermediate Of Remdesivir
Product Description
| Appearance | White powder |
| GS Standard | 99.5%min |
| CAS | 1191237-69-0 |
GS-441524 is both just like or stronger than remdesivir in opposition to SARS-CoV-2 in mobileular subculture, with a few researchers arguing that GS-441524 might be higher than remdesivir for the remedy of COVID-19.Specific benefits stated encompass ease of synthesis, decrease kidney and hepatotoxicity, in addition to capacity for oral delivery (that is precluded of remdesivir due to terrible hepatic balance and primary byskip metabolism). The public fitness advocacy group, Public Citizen, in an open letter advised the DHHS and Gilead to analyze GS-441524 for the remedy of COVID-19, suggesting that GILEAD become now no longer doing so for economic reasons associated with the longer highbrow belongings lifespan of Remdesivir. Direct efficacy in opposition to SARS-CoV-2 become proven in a mouse version of COVID-19. A deuterium changed model of GS-441524 has been produced and has proven pre-medical efficacy in each mobileular subculture and mouse fashions through a group together with individuals of Wuhan Institute of Virology.
Intracellular triple-phosphorylation of GS-441524 yields its energetic 1'-cyano-substituted adenosine triphosphate analogue, which immediately disrupts viral RNA replication with the aid of using competing with endogenous NTPs for incorporation into nascent viral RNA transcripts and triggering not on time chain termination of RNA-structured RNA polymerase.
