Manufacturer Supply Phenformin Price CAS 114-86-3 Raw Powder 99% Purity Phenformin
Product Description
Product Name: Phenformin
CAS: 114-86-3
MF: 10H15N5
MW: 05.26
EINECS:204-057-4
Appearance: white powder
Phenformin, a biguanide with oral hypoglycaemic activity, was introduced in 1957 for the management of diabetes mellitus. By 1970 its use had been associated with incidences of lactic acidosis and by 1976 clinical studies had conclusively demonstrated that the hazards of phenformin treatment outweighed the benefits. Preparations containing phenformin were withdrawn in several countries and their use restricted in others. Elsewhere, however, proprietary preparations containing this drug may remain available. The related biguanide, buformin, has been also associated with lactic acidosis and has been subjected to similar restrictions as phenformin, whereas there is some evidence that metformin is less liable to induce lactic acidosis.
Function and Application
Phenformin is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity. It has been shown to increase AM.PK activity without increasing AMP/ATP activity. A particular study has shown that treating hearts with phenformin hydrochloride and then perfusing with Krebs-Henseleit buffer increased AMP and AM.PK activity and elevated phosphorylated acetyl-CoA carboxylase. Phenformin hydrochloride increases phosphorylation and AM.PK activity in the isolated heart, and this increase has always been correlated with and preceded by increased cytosolic.
