Professional Supply Ribociclib Succinate Lee011 Powder Anticancer CAS: 1374639-75-4
Product Description
| Product Name | Manufacturer Supply Raw Material CAS 1374639-75-4 Ribociclib powder |
| Appearance | white powder |
| CAS | 1374639-75-4 |
| Assay | 99% |
| Keywords | Apis Ribociclib;Raw Material Ribociclib;bulk Ribociclib powder |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Ribociclib does not currently have Marketing Authorisation in the EU for any indication. Ribociclib is in phase II studies for breast cancer.
Function and Application
1. A CDK4/6 inhibitor.
2. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating.
3. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to alone at the first pre-planned interim analysis.
