High-Quality CAS 26159-34-2 Naproxen Sodium with Manufacturer Supply
Naproxen sodium (NS) is a sodium salt of propio nic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
| CAS |
26159-34-2 |
| Name |
Naproxen sodium |
| Appearance |
white powder |
| Molecular Formula |
C14H13NaO3 |
| Molecular Weight |
252.241 |
| PSA |
49.36 |
| LOGP |
1.7018 |
| Boiling point |
403.9ºC |
| Melting point |
250-251ºC |
| Flash point |
154.5ºC |
| Storage condition |
Inert atmosphere,Room Temperature |
Application
Naproxen sodium has strong anti-inflammatory and analgesic effects, and its main biological effects are:
(1) Inhibit the activity of prostaglandin synthase, thereby reducing capillary permeability;
(2) Reduce the production of superoxide by macrophages to play an anti-inflammatory effect;
(3) Stimulate T inhibitory cell activity;
(4) Reduce pain sensitivity. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect is similar, but the incidence and severity of adverse reactions in the gastrointestinal tract and nervous system are lower.
Function
Naproxen sodium is a kind of non-steroidal anti-inflammatory analgesic that is easier to be tolerated by humans. It belongs to the phenylpropionic acid compound and exerts anti-inflammatory and analgesic effects by inhibiting the synthesis of prostaglandins.
It is clinically suitable for alleviating various mild to moderate pains, such as pain after tooth extraction and other operations, primary dysmenorrhea and headaches. It is also suitable for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis (Juvenilearthritis), tendinitis, bursitis and acute gouty arthritis. Limits have the effect of relieving symptoms. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the effect of symptom relief is similar.
