Factory Supply Raw material Powder Ambrisentan CAS 177036-94-1
Product Description
Ambrisentan (U.S. trade name Letairis; E.U. trade name Volibris; India trade name Pulmonext by MSN labs) is a drug indicated for use in the treatment of pulmonary hypertension.
| Product Name | Ambrisentan |
| MOQ | 1kg |
| CAS | 177036-94-1 |
| Appearance | white |
| Molecular Formula | C22H22N2O4 |
| Molecular Weight | 378.42 |
| Assay | >99% |
| Application | For research purpose only |
| Packing | 25kg/drum |
| Storage | Store in a well-closed,light-resistant container |
| Remarks | NA |
| Custom synthesis | Available |
Function and Application
The peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2).Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), and designated an orphan drug, for the treatment of pulmonary hypertension.
