| Product Name | GS-441524 |
| Expiry Date | 1 Year From The Date Of Manufacture |
| Storage Condition | Room Temperature |
| CAS | 1191237-69-0 |
| Function | Treatment For Cat FIP |
| Dosage Form | Injection |
| Country of Manufacture | China |
| Packaging | 6ml/vial, 8ml/vial, 10ml/vial |
| Strength | 30mg/ml |
GS-441524 is a nucleoside analog, which acts as an alternative substrate and RNA-chain terminator for the viral RNA dependent RNA polymerase. In simpler terms, it interjects itself in the chain reaction and prevents the replication of the virus. This action stops the spread of the virus to other cells, thereby enabling the immune system to build a complete immune response. It is a main metabolite of the antiviral prodrug remdesivir, and has a half-life of 24 hours in human patients.
In animals, GS-441524 and remdesivir were both found to be effective against feline coronavirus strains responsible for feline infectious peritonitis (FIP). FIP is a severe systemic disease that affects domestic cats. Cats with a healthy and active immune system will generally be able to fight off an infection or virus with the help of their white blood cells. However, cats with FIP usually have an immune defect or deficiency that causes the white blood cells to replicate the virus instead of fighting it off. This can lead to either wet FIP (no immune response) or dry FIP (partial immune response).
Recommended dosage:
FIP(Wet): 0.3ml/kg * body weight kg + 0.1ml residue
FIP (Dry): 0.4ml/kg * body weight kg + 0.1ml residue
Eye / nerve entry: 0.5ml/kg * body weight kg + 0.1ml residue
Recurrence: 0.6 ml / kg * body weight kg + 0.1ml residue
