Minoxidil sulfate is a metabolite of minoxidil, the medication primarily used to treat hair loss. When minoxidil is applied topically to the scalp, it undergoes metabolism in the body, and one of its primary metabolites is minoxidil sulfate.
Minoxidil sulfate is believed to be the active form responsible for the vasodilatory effects that promote hair growth. It works by dilating blood vessels in the scalp, which increases blood flow to hair follicles, thereby promoting hair growth and preventing hair loss.
Unlike minoxidil, which itself is a direct vasodilator, minoxidil sulfate is considered more potent in terms of its ability to open potassium channels in cells, which leads to the relaxation of smooth muscle cells and the dilation of blood vessels. This increased blood flow to hair follicles is believed to stimulate hair growth.
Some commercial preparations of minoxidil may include minoxidil sulfate as part of their formulation, alongside minoxidil itself. However, the exact proportions and concentrations of minoxidil sulfate in these formulations can vary.
| Product name | Minoxidil Sulphate |
| Cas | 83701-22-8 |
| Appearance | White Powder |
| Specification | 99% |
| Type | Raw Materials |
| Package | 1Kg/25Kg/Drum or As per your request |
| Storage | Store in cool and dry places ,keep away from strong light |
| Shelf life | 2 years when properly stored |
| Safety |
Non-toxic, non-stimulating, safe and reliable |
Minoxidil sulfate plays a significant role in the mechanism of action of minoxidil, particularly in its effectiveness in treating hair loss. Here's a detailed look at its functions and contributions:
1. Vasodilation: Minoxidil sulfate is a potent vasodilator. It works by opening potassium channels in vascular smooth muscle cells, leading to relaxation of these cells and subsequent dilation of blood vessels. This vasodilatory effect increases blood flow to the hair follicles in the scalp.
2. Increased Blood Flow: By dilating blood vessels in the scalp, minoxidil sulfate enhances the delivery of oxygen, nutrients, and other essential substances to the hair follicles. This improved circulation is crucial for maintaining follicular health and supporting hair growth.
3. Stimulation of Hair Follicles: The enhanced blood flow and nutrient supply due to minoxidil sulfate's vasodilatory action stimulate hair follicles that are in the resting phase (telogen phase) to transition to the growth phase (anagen phase). This results in increased hair density and thicker hair shafts over time.
4. Complementary Action with Minoxidil: While both minoxidil and its sulfate form contribute to the overall effectiveness of topical minoxidil formulations, minoxidil sulfate is believed to be particularly responsible for the sustained vasodilatory effects that promote long-term hair growth.
5. Clinical Use: Topical minoxidil formulations containing both minoxidil and its sulfate metabolite are widely used for the treatment of androgenetic alopecia (male and female pattern hair loss). These formulations are available over-the-counter and by prescription, depending on the concentration.
6. Research and Understanding: Although the exact contribution of minoxidil sulfate versus minoxidil itself in hair growth stimulation is still under study, it is clear that both forms play crucial roles in the therapeutic effects observed in individuals using minoxidil for hair loss treatment.
In summary, minoxidil sulfate functions primarily as a potent vasodilator that enhances blood flow to hair follicles, thereby promoting hair growth and improving hair density in individuals experiencing hair loss.
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