| Product Name | GS-441524 |
| Expiry Date | 1 Year From The Date Of Manufacture |
| Storage Condition | Room Temperature |
| CAS | 1191237-69-0 |
| Function | Treatment For Cat FIP |
| Dosage Form | Injection |
| Country of Manufacture | China |
| Packaging | 6ml/vial, 8ml/vial, 10ml/vial |
| Strength | 20mg and 30mg |
GS-441524 injection solution is an antiviral medication used in the treatment of Feline Infectious Peritonitis (FIP), a severe and often fatal disease in cats caused by a mutated feline coronavirus. As a nucleoside analog, GS-441524 works by inhibiting the replication of the virus within the cat's cells, effectively reducing the viral load and allowing the immune system to manage the infection. The injection solution is administered subcutaneously, offering a direct and efficient delivery method for the medication. While not officially approved for veterinary use in many regions, GS-441524 injection solution has shown remarkable success in clinical studies and anecdotal reports, helping numerous cats achieve remission from FIP. This form of the drug is particularly useful for cats with severe or advanced cases of FIP, where rapid and intensive treatment is necessary. However, challenges such as cost, access, and the potential for drug resistance remain concerns for veterinarians and pet owners.
"FIP" refers to Feline Infectious Peritonitis (FIP), which is a viral disease caused by certain strains of feline coronavirus (FCoV).
Cause: FIP is caused by a mutation of the feline coronavirus (FCoV). Most cats with FCoV do not develop FIP, but in some cases, the virus mutates into a form that causes FIP.
Transmission: FCoV is commonly spread through feces and oral-fecal transmission, often in multi-cat environments such as shelters or catteries. Once a cat is infected with FCoV, it may develop either a mild, self-limiting form of the disease or progress to FIP.
Forms of FIP: FIP presents in two main forms: effusive (wet) and non-effusive (dry). Effusive FIP involves the accumulation of fluid in body cavities, such as the abdomen or chest. Non-effusive FIP is characterized by granulomatous lesions in various organs.
Symptoms: Symptoms of FIP can vary widely and may include fever, weight loss, lethargy, jaundice, difficulty breathing, and fluid accumulation in the abdomen or chest in the case of effusive FIP. Neurological symptoms can also occur in some cases.
Diagnosis: FIP can be challenging to diagnose definitively, as clinical signs and laboratory tests are often non-specific. Diagnosis may involve a combination of clinical evaluation, laboratory tests (such as bloodwork, imaging, and fluid analysis), and sometimes histopathology.
Prevention: Prevention of FIP focuses on reducing exposure to FCoV. This includes minimizing stress, maintaining good hygiene and sanitation practices, and reducing overcrowding in multi-cat environments. Vaccines for FIP are available, but their efficacy remains controversial.
GS-441524 is an antiviral drug that has shown promise in the treatment of feline infectious peritonitis (FIP), a viral disease caused by certain strains of feline coronavirus. As of my last update, GS-441524 is primarily used off-label in cats with FIP.
The dosage of GS-441524 injection for cats with FIP can vary depending on factors such as the cat's weight, the severity of the disease, and the veterinarian's assessment. Dosage regimens may also vary based on individual response and the specific formulation of GS-441524 being used.
Recommended dosage:
FIP(Wet): 0.3ml/kg * body weight kg + 0.1ml residue
FIP (Dry): 0.4ml/kg * body weight kg + 0.1ml residue
Eye / nerve entry: 0.5ml/kg * body weight kg + 0.1ml residue
Recurrence: 0.6 ml / kg * body weight kg + 0.1ml residue
