Phenibut HCl powder is a synthetic compound developed as a derivative of the neurotransmitter gamma-aminobutyric acid (GABA), primarily used for its anxiolytic, nootropic, and mood-enhancing properties. Originally synthesized in the Soviet Union in the 1960s, Phenibut was created to help manage anxiety and stress without the sedative effects often associated with other GABA-related compounds. By crossing the blood-brain barrier effectively, Phenibut binds to GABA receptors in the brain, promoting a calming effect that can help alleviate symptoms of anxiety, stress, and social discomfort.
In addition to its anxiolytic properties, Phenibut may also interact with dopamine receptors, contributing to enhanced mood, motivation, and mild euphoria, which makes it attractive to individuals seeking relief from depressive symptoms or those looking to improve social confidence. Its cognitive-enhancing (nootropic) effects include improved focus, mental clarity, and motivation, especially in high-stress or high-performance situations. Phenibut is also used to promote better sleep quality due to its calming influence, which can help ease insomnia and restless sleep.
The hydrochloride (HCl) form of Phenibut is water-soluble, making it easy to measure and mix for precise dosing. However, Phenibut’s effects on the GABA and dopamine systems mean it carries a risk of tolerance, dependency, and withdrawal if used frequently. For these reasons, Phenibut is often recommended for occasional use, with moderate doses and strict intervals between uses to prevent adverse effects. In many countries, it remains unregulated, but some have placed restrictions due to its potential for misuse. Despite these risks, when used responsibly and under proper guidance, Phenibut HCl can be a beneficial supplement for anxiety relief, mood enhancement, and cognitive support.
Product name | Phenibut HCl |
CAS NO | 3060-41-1 |
Molecular formula | C10H14ClNO2 |
Molecular weight | 215.68 |
Assay | 99% |
Appearance | White Powder |
Usage | New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment. |
Standard | Enterprise standard |
MP | 194-201°C |
Minimum order quantity | 10g |
1. Anxiety Reduction: By enhancing GABA activity in the brain, Phenibut has a calming effect, which helps to alleviate anxiety. It can be used to support relaxation, reduce social anxiety, and help manage stress levels. Unlike GABA itself, Phenibut is able to cross the blood-brain barrier, allowing it to act directly on the central nervous system.
2. Mood Enhancement: Phenibut is also believed to interact with dopamine receptors, which can enhance mood and create mild euphoric effects in some users. This dopamine activity may contribute to a feeling of well-being, often making it popular as a mood-support supplement.
3. Improving Sleep Quality: Due to its calming and sedative effects, Phenibut is sometimes used to improve sleep quality. At lower doses, it may help to relax the body and mind, supporting deeper, more restful sleep.
4. Cognitive Enhancement: Phenibut may have nootropic effects that improve mental clarity, focus, and motivation, especially in high-stress situations. It is sometimes used by people looking to maintain composure and cognitive performance under pressure.
1. Dosage: Phenibut is often effective at low doses. Initial dosing recommendations vary, but typical ranges are between 250 mg to 500 mg. Starting at the lower end (250 mg) allows the body to adjust and helps gauge individual response. It is crucial to avoid taking more than 1000 mg daily, as higher doses increase the risk of tolerance and side effects.
2. Frequency: Due to the risk of tolerance, Phenibut should not be used daily. Many users limit their intake to one or two times per week, allowing time for the body to clear the compound fully and reducing the risk of dependency. Taking it less frequently also helps maintain its effectiveness when used for occasional stress or anxiety relief.
3. Timing: Phenibut typically takes 2 to 4 hours to reach peak effects, so timing is important. It’s often taken in the morning or early afternoon, especially if used for social anxiety or mood enhancement. Since it has a long half-life, effects can last several hours, and taking it too late in the day may interfere with sleep.
4. Cycling: To prevent tolerance and reduce dependency risks, many users follow a cycling approach, using Phenibut for short periods followed by breaks. For instance, some users take it weekly or bi-weekly, giving ample time between doses to prevent habituation.
Precautions: Due to its GABAergic effects, Phenibut can cause sedation, dizziness, and, at high doses, more severe side effects such as nausea or impaired coordination. Stopping use after prolonged intake can lead to withdrawal symptoms, so moderation and adherence to dosage limits are critical.
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