| Product Name | GS-441524 |
| Expiry Date | 1 Year From The Date Of Manufacture |
| Storage Condition | Room Temperature |
| CAS | 1191237-69-0 |
| Function | Treatment For Cat FIP |
| Dosage Form | Injection |
| Country of Manufacture | China |
| Packaging | 6ml/vial, 8ml/vial, 10ml/vial |
| Strength | 20mg and 30mg |
GS-441524 is a nucleoside analog, which acts as an alternative substrate and RNA-chain terminator for the viral RNA dependent RNA polymerase. In simpler terms, it interjects itself in the chain reaction and prevents the replication of the virus. This action stops the spread of the virus to other cells, thereby enabling the immune system to build a complete immune response. It is a main metabolite of the antiviral prodrug remdesivir, and has a half-life of 24 hours in human patients.
In animals, GS-441524 and remdesivir were both found to be effective against feline coronavirus strains responsible for feline infectious peritonitis (FIP). FIP is a severe systemic disease that affects domestic cats. Cats with a healthy and active immune system will generally be able to fight off an infection or virus with the help of their white blood cells. However, cats with FIP usually have an immune defect or deficiency that causes the white blood cells to replicate the virus instead of fighting it off. This can lead to either wet FIP (no immune response) or dry FIP (partial immune response).
For cats suffering from wet FIP, which is characterized by the abnormal accumulation of fluid in the abdomen or chest cavity, GS - 441524 injection can lead to a rapid reduction in fluid build - up. In dry FIP cases, where the disease often affects internal organs such as the eyes, nervous system, or abdominal organs, the injection helps in alleviating symptoms like neurological deficits, ocular inflammation, and organ - related dysfunctions. Cats on treatment often experience a restoration of normal bodily functions, with improved energy levels, better coat condition, and a return to their usual playful and social behaviors.
The injection is administered subcutaneously, which allows for relatively easy administration, even in a home - based setting with proper training. The treatment protocol is highly individualized, taking into account factors such as the cat's overall health, the stage of the disease, and its body weight. Usually, treatment courses range from 8 - 12 weeks, during which close monitoring of the cat's condition is essential.
Regular veterinary check - ups, including blood tests and physical examinations, are carried out to assess the cat's response to treatment and to make any necessary adjustments to the dosage.
Recommended dosage:
FIP(Wet): 0.3ml/kg * body weight kg + 0.1ml residue
FIP (Dry): 0.4ml/kg * body weight kg + 0.1ml residue
Eye / nerve entry: 0.5ml/kg * body weight kg + 0.1ml residue
Recurrence: 0.6 ml / kg * body weight kg + 0.1ml residue
