20mg/mL Remdesivir GS441 FIP Treatment In Cats GS Drug
Product Description
GS-441524 is a nucleoside analogue antiviral drug which became advanced with the aid of using Gilead Sciences. It is the primary plasma metabolite of the antiviral prodrug remdesivir, and has a half-existence of round 24 hours in human patients. Remdesivir and GS-441524 had been each located to be powerful in vitro in opposition to tom cat coronavirus traces liable for tom cat infectious peritonitis (FIP), a deadly systemic ailment affecting home cats. Remdesivir became in no way examined in cats (aleven though a few vets now provide it[1]), however GS-441524 has been located to be powerful remedy for FIP and is extensively used regardless of no authentic FDA approval because of Gilead's refusal to license this drug for veterinary use.
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Appearance |
Transparent liquid, powder or tablets |
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GS Standard |
99.5%min |
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Size |
5.5 ml/ Vial |
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Content |
15mg/ml or 20mg/ml |
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Application |
For CAT FIP R&D Use ONLY |
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Wet FIP |
6-7 mg/kg |
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Dry FIP |
7-8 mg/kg |
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Ocular or Neuro FIP |
8 mg/kg |
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Increased ocular/neuro |
9 mg/kg |
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Max ocular/neuro |
10 mg/kg |
What is FIP?
Neurogenic Feline Infectious Peritonitis (FIP) is a serious disease in cats caused by mutations in the common feline intestinal (gut) coronavirus (FeCoV). The mutation allows the otherwise trivial virus to enter intestinal macrophages (a type of immune system cell) and hitch a ride to other parts of the body, infecting the abdominal cavity, chest cavity, eyes and certain parts of the gastrointestinal tract to escape the lining of the gastrointestinal tract. Example, the brain. Normally, the feline immune system prevents clinical FIP, but in some cats infected with intestinal FeCoV, the immune system is unable to eliminate the infection and the development of clinical FIP can have devastating consequences.
Over 30% of pet cats and over 80% of breeding cats have been exposed to FeCoV (the relatively harmless intestinal form).
While the relatively harmless enteric coronavirus (FeCoV) is highly transmissible among cats, the mutated form of FIP itself does not infect other cats, and feline coronaviruses are different from the human coronaviruses that cause COVID-19.
Clinical symptoms of FIP
Cats with clinical FIP will show a range of clinical signs, such as:
(1) Fever not responding to antibiotics
(2) Fluid in the abdominal and/or chest cavity
(3) Palpable swollen lymph nodes in the abdomen
(4) Symmetrical changes in pupil or eye color
(5) Neurological signs (brain infection)
Clinical signs depend on whether the cat has an exudative or "wet" form of FIP or a non-exudative or "dry" form of FIP, although there is often a combination of wet and dry forms known as "mixed wet and dry" FIP.
Dry FIP is often more difficult to diagnose because there is no apparent fluid-filled body cavity to sample, but rather a focal (eg, bowel or kidney) or multiple site (eg, abdominal cavity, brain) pus granuloma formation.
FAQ
Q: What is GS441?
A: GS is short for GS which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field .
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please checking with Julia for the details!
Q: How long is the treatment?
A: Recommended treatment based on Niche Petcare is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat's symptoms should be assessed to see if additional treatment is needed.
Q: What is the correct dose of GS441 to give my kitty?
A: Dosing is based on the weight of the cat.
If you love math, the formula to calculate is:
5mg*(GS) x weight(kg) / GS concentration per 1mL**=dose per 24hr
*Neurological and Ocular FIP cats require 8mg/kg MINIMUM.
Can go as high as 10mg/kg for extreme ocular or neurological cases.
*GS concentration per 1ml = total GS in bottle (mg) / total solution volume (mL)
Q: What exactly are "neuro" or "ocular" cases?
A: "Neuro" cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected
Q: How long after completing FIP treatment should I wait to spay/neuter my cat?
A: 3 months.
