Semaglutide is a medication used in the treatment of type 2 diabetes and obesity. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. These medications work by mimicking the action of the natural hormone GLP-1, which helps regulate blood sugar levels by stimulating insulin release, reducing glucagon secretion, and slowing gastric emptying.
Semaglutide is administered by injection under the skin (subcutaneously) and is typically taken once weekly. It helps to improve glycemic control in people with type 2 diabetes by lowering blood sugar levels, reducing HbA1c levels (a measure of long-term blood sugar control), and promoting weight loss. Additionally, semaglutide has been found to have cardiovascular benefits in people with type 2 diabetes, reducing the risk of major adverse cardiovascular events such as heart attack and stroke.
In addition to its use in diabetes management, semaglutide has also been studied for its potential in the treatment of obesity. In this context, it is administered at a higher dose and has been found to lead to significant weight loss in combination with lifestyle modifications.
| Product Name | Semaglutide Peptide |
|---|---|
| Storage Conditions | Store At 2-25°C |
| Test Method | HPLC UV |
| Form | 99% Raw Powder |
| COA | Available |
| Indication | Weight Loss |
| Shelf Life | 2 Years |
| CAS | 910463-68-2 |
| Active Ingredient | Semaglutide |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
The function of semaglutide revolves around its role as a glucagon-like peptide-1 (GLP-1) receptor agonist. Here's a breakdown of how semaglutide works and its key functions:
1. GLP-1 Receptor Activation: Semaglutide binds to and activates GLP-1 receptors, which are found on various cells throughout the body, including pancreatic beta cells, gastrointestinal cells, and neurons in the brain.
2. Insulin Release: One of the primary functions of semaglutide is to stimulate the secretion of insulin from pancreatic beta cells in response to elevated blood glucose levels. This helps lower blood sugar levels after meals, promoting better glycemic control in individuals with type 2 diabetes.
3. Glucagon Suppression: Semaglutide also reduces the secretion of glucagon, a hormone that raises blood sugar levels. By inhibiting glucagon release, semaglutide helps prevent excessive glucose production by the liver, contributing to overall blood sugar regulation.
4. Slowing Gastric Emptying: Another important function of semaglutide is its ability to slow down the emptying of food from the stomach into the small intestine. This delayed gastric emptying leads to a slower and more gradual rise in blood glucose levels after meals, helping to prevent postprandial hyperglycemia (high blood sugar levels after eating).
5. Appetite Regulation: Semaglutide can also impact appetite and satiety. By activating GLP-1 receptors in the brain's appetite control centers, it promotes feelings of fullness and reduces food intake, which can be beneficial for weight management in individuals with obesity.
6. Weight Loss: The combination of reduced appetite, slower gastric emptying, and improved glycemic control often leads to weight loss in individuals taking semaglutide. This weight loss effect is particularly notable in higher doses used specifically for obesity treatment.
7. Cardiovascular and Renal Benefits: Beyond its effects on blood sugar and weight, semaglutide has demonstrated additional benefits such as improvements in cardiovascular risk factors (e.g., blood pressure, cholesterol levels) and potential renal protective effects in certain patient populations.
Overall, the function of semaglutide is multifaceted, encompassing improvements in blood sugar control, appetite regulation, weight management, and potential cardiovascular and renal benefits. Its mechanism of action as a GLP-1 receptor agonist makes it a valuable medication for the treatment of type 2 diabetes, obesity, and related metabolic conditions.
