Semaglutide is a synthetic analog of the human glucagon-like peptide-1 (GLP-1) hormone. GLP-1 is released from the intestine in response to food intake and plays a crucial role in regulating blood sugar levels. It stimulates insulin secretion from pancreatic beta cells, suppresses glucagon secretion (which helps lower blood sugar levels), slows down gastric emptying, and reduces appetite.
Semaglutide works by binding to and activating GLP-1 receptors in various tissues, including pancreatic beta cells, where it enhances insulin secretion in a glucose-dependent manner. This means that semaglutide primarily acts when blood sugar levels are elevated, helping to lower them without causing hypoglycemia (low blood sugar) when levels are normal. It also suppresses glucagon secretion, which further contributes to its blood sugar-lowering effects.
| Product Name | Semaglutide Peptide |
|---|---|
| Storage Conditions | Store At 2-25°C |
| Test Method | HPLC UV |
| Form | 99% Raw Powder |
| COA | Available |
| Indication | Weight Loss |
| Shelf Life | 2 Years |
| CAS | 910463-68-2 |
| Active Ingredient | Semaglutide |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
The function of semaglutide revolves around its role as a glucagon-like peptide-1 (GLP-1) receptor agonist. Here's a breakdown of how semaglutide works and its key functions:
1. GLP-1 Receptor Activation: Semaglutide binds to and activates GLP-1 receptors, which are found on various cells throughout the body, including pancreatic beta cells, gastrointestinal cells, and neurons in the brain.
2. Insulin Release: One of the primary functions of semaglutide is to stimulate the secretion of insulin from pancreatic beta cells in response to elevated blood glucose levels. This helps lower blood sugar levels after meals, promoting better glycemic control in individuals with type 2 diabetes.
3. Glucagon Suppression: Semaglutide also reduces the secretion of glucagon, a hormone that raises blood sugar levels. By inhibiting glucagon release, semaglutide helps prevent excessive glucose production by the liver, contributing to overall blood sugar regulation.
4. Slowing Gastric Emptying: Another important function of semaglutide is its ability to slow down the emptying of food from the stomach into the small intestine. This delayed gastric emptying leads to a slower and more gradual rise in blood glucose levels after meals, helping to prevent postprandial hyperglycemia (high blood sugar levels after eating).
5. Appetite Regulation: Semaglutide can also impact appetite and satiety. By activating GLP-1 receptors in the brain's appetite control centers, it promotes feelings of fullness and reduces food intake, which can be beneficial for weight management in individuals with obesity.
6. Weight Loss: The combination of reduced appetite, slower gastric emptying, and improved glycemic control often leads to weight loss in individuals taking semaglutide. This weight loss effect is particularly notable in higher doses used specifically for obesity treatment.
