Retatrutide is a novel triple agonist that targets three important receptors involved in metabolic regulation: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and the glucagon receptor (GCGR). By simultaneously activating these receptors, Retatrutide produces a powerful and synergistic therapeutic effect, making it a promising candidate for the treatment of obesity and type 2 diabetes. Activation of the GLP-1 and GIP receptors enhances glucose-dependent insulin secretion, suppresses appetite, and improves glycemic control, while stimulation of the glucagon receptor helps increase energy expenditure and promote fat metabolism. This unique multi-receptor mechanism enables Retatrutide to address several aspects of metabolic dysfunction at once. In clinical trials, it has shown the potential to achieve unprecedented weight loss, with some participants losing up to 24% of their body weight over a 48-week period.
| Product Name | Retatrutide Peptide |
| Shelf Life | 2 Years |
| Form | Peptide |
| Indication | Weight Loss |
| Dosage | 1mg~12mg/week |
| Active Ingredient | Retatrutide |
| Storage Conditions | Store At 2-25°C |
| Packaging | 10mg/vial, 15mg/vial, 20mg/vial, 30mg/vial, 40mg/vial |
The function of Retatrutide revolves around its ability to target and activate three key receptors involved in metabolic regulation: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and GCGR (glucagon receptor). This triple agonist mechanism leads to several beneficial effects for individuals with obesity and type 2 diabetes:
1. Blood Sugar Control:
Retatrutide enhances insulin secretion in a glucose-dependent manner (via GLP-1 and GIP receptors), helping to lower blood sugar levels.
It reduces glucagon levels, which helps prevent excessive glucose production by the liver.
2. Appetite Suppression:
By activating the GLP-1 and GIP receptors, Retatrutide helps reduce hunger and increase feelings of fullness, leading to reduced calorie intake.
3. Weight Loss:
Through its combined effects on appetite regulation and energy expenditure, Retatrutide promotes significant weight loss, with some trials showing up to 24% body weight reduction.
4. Increased Energy Expenditure:
Activation of the GCGR receptor boosts calorie burning and fat metabolism, contributing to weight loss and overall metabolic health.
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