Product Description
Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively. It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy. It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day. Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury. Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
| Product Name | 99% Sildenafil |
| CAS No. | 139755-83-2 |
| EINECS No. | 200-659-6 |
| Appearance | White powder |
| Molecular formula | C22H30N6O4S |
| Molecular Weight | 666.70 |
| Usage | Male Sex Powder |
| Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
| Shelf Life | 24 Months |
1. Activate libido within 15 to 30 minutes.
2. Prolong the time of sexual intercourse.
3. Sildenafil enhances sexual stamina, get the natural harder and stronger erection.
4. Sildenafil is used to treat ED ( Erectile Dysfunction) effectively.
5. No harmful side effect,safe without addiction.
